Which of the following side effects would you not expect from carbonic anhydrase inhibitors?

The side effect of changing the color of the iris is not typically associated with carbonic anhydrase inhibitors. These medications primarily function by inhibiting the enzyme carbonic anhydrase, which plays a role in regulating fluid balance and pressure within the eye. The expected side effects of carbonic anhydrase inhibitors may include increased intraocular pressure, fatigue, and loss of appetite.

While the other options can arise from the pharmacological effects of carbonic anhydrase inhibitors, changes in iris pigmentation are more characteristic of certain other medications, such as those used in glaucoma treatment, particularly prostaglandin analogs. Thus, the absence of iris color change as a side effect directly supports the idea that this option is not aligned with the pharmacological profile of carbonic anhydrase inhibitors.